Meclozine + Pyridoxine

Oral
Pregnancy-associated nausea and vomiting

Prostate hypertrophy, obstruction of bladder neck, narrow angle glaucoma, pyloric stenosis. May impair ability to drive or operate machinery. Pregnancy.

Drowsiness, thickening of bronchial secretions, dry mouth, fatigue, blurred vision.

Meclozine: Additive effects with CNS depressants, neuroleptics, anticholinergics, alcohol.

Pyridoxine: May cause false-positive results for urobilinogen in the spot test using Ehrlich's reagent.

Description:
Mechanism of Action: Meclozine hydrochloride, a piperazine derivative, is a sedating antihistamine with antimuscarinic properties. It is mainly used in the prevention and treatment of nausea and vomiting associated with a variety of conditions.
Onset: Meclozine: 1 hr
Duration: Meclozine: 8-24 hr
Pharmacokinetics:
Absorption: Pyridoxine: Readily absorbed from GI tract except in malabsorption syndromes or following gastric resection.
Metabolism: Pyridoxine: Converted to pyridoxal phosphate and pyridoxamine phosphate in the liver; riboflavin needed for further conversion of pyridoxine phosphate to pyridoxal phosphate which are the principal forms of the vitamin in the blood. Pyridoxal is further oxidised to 4-pyridoxic acid in liver.
Excretion: Meclozine: Plasma half-life: 6 hr. Pyridoxine: Excreted in urine (4-pyridoxic acid).

Store below 25°C.

Antiemetics